If you have hypermobile joints and pain, the first question is what is causing the pain and what would improve function. PRP is not an established general treatment for joint hypermobility or a substitute for a diagnosis and rehabilitation plan. A painful tendon, an unstable joint and osteoarthritis are different problems, even when they occur in the same person.
An assessment should connect the symptoms, examination and previous treatment before discussing an injection. The aim is a plan that fits your joint and daily life, rather than treating flexibility itself as something that needs a procedure.
Hypermobility is not one diagnosis
Some people have a wide range of movement without pain or disability. Others experience recurrent sprains, instability, subluxations or dislocations, or have a recognised hypermobility-related condition. Hypermobile Ehlers-Danlos syndrome has clinical diagnostic criteria; a flexible joint or a social-media checklist is not enough to establish it.
Tell the clinician about previous diagnoses, dislocations, injuries, easy bruising, treatment and any specialist involvement. Describe whether pain follows an injury, develops with repeated activity or is present across several areas. A scan can help answer a specific question, but it does not replace that history.
Discuss the assessment route with The London PRP Clinic. Explain that hypermobility or a connective-tissue diagnosis is part of your history before arranging treatment. Confirm whether the proposed clinician and setting are appropriate for the problem.
Identify the target before choosing an injection
An injection needs a clearly defined target and reason. Ask whether the symptoms arise from a tendon, joint surface, instability, nerve irritation or another cause. If the joint repeatedly gives way, simply reducing pain would not necessarily address the mechanical problem.
Ask what examination findings or imaging support the diagnosis and what alternatives remain plausible. A report showing a small structural change does not prove that change is the main source of pain. The useful discussion explains how the proposed treatment connects to your symptoms and functional goals.
There is no basis here to promise that PRP tightens all loose ligaments, corrects a connective-tissue condition or prevents future dislocations. Evidence about PRP in a particular tendon disorder or osteoarthritis should not be presented as evidence for treating hypermobility as a whole.
A stability and loading plan matters
GeneReviews describes tailored exercise to improve strength, proprioception and joint stability as part of managing hypermobile Ehlers-Danlos syndrome. It also describes options such as braces, splints and occupational support where appropriate. That is an individual programme, not a prescription for everyone to perform the same exercises or stop all activity.
Tell the clinician what rehabilitation you have tried, whether it was supervised, what helped and what made symptoms worse. Pain, fatigue and instability can affect progression. A workable plan should explain how loading will be adjusted and when the response will be reviewed.
If an injection is considered for a separate diagnosed problem, ask how it fits that programme. An injection should not leave you without guidance about safe activity, work tasks and the route back to the movements that matter to you.
Share bleeding, medicine and previous-procedure information
Tell the team about easy or prolonged bleeding, significant bruising, medicines and supplements, previous reactions to injections and problems with wound healing. Different connective-tissue conditions have different implications; do not assume advice for one diagnosis applies to another.
Do not stop prescribed aspirin, anticoagulants or other treatment because of a generic PRP leaflet. Any proposed change needs agreement with the clinician responsible for that medicine. Explain if positioning, fatigue, dizziness or pain makes a standard procedure appointment difficult, so the team can consider the practical plan.
What would count as a worthwhile result?
Choose specific goals before treatment: walking a familiar distance, managing stairs, sleeping more comfortably or returning to a particular task. Record the starting point and agree when progress will be assessed. Improvement in one pain score does not necessarily mean instability has resolved.
Ask what would prompt reconsideration, referral or a different treatment. A course should not continue automatically because a package has been purchased. Discuss the complete assessment and treatment fees, rehabilitation arrangements and follow-up before committing.
Contact The London PRP Clinic to discuss a diagnosis-led review. Bring specialist letters, relevant imaging reports and a short account of previous rehabilitation. An assessment may identify a role for a procedure, further specialist input or a non-injection plan.
When not to wait for a routine appointment
A newly deformed joint, inability to use a limb after an injury, new loss of sensation or circulation concerns needs prompt medical assessment. A hot, markedly swollen joint with fever or feeling unwell also needs urgent care. Do not assume a new severe problem is simply another episode of familiar hypermobility pain.
Evidence and scope
General adult information, not a diagnosis or a treatment recommendation for a particular connective-tissue condition. Source checked 6 November 2026. GeneReviews supports the assessment and management discussion; it does not establish PRP as treatment for hypermobility.
GeneReviews: hypermobile Ehlers-Danlos syndrome, diagnosis and management.