Polynucleotides Under Eyes London. Dark Circles, Crepey Skin And What To Expect
Polynucleotides are one of the most asked about under-eye treatments in London right now, and for good reason. They are purified DNA fragments, usually salmon derived, that improve the quality and thickness of the delicate skin beneath the eye rather than adding volume. For tired-looking, crepey or shadowed under-eyes, that is often exactly the right tool. They thicken the skin instead of filling it.
This guide is written by the medical team at The London PRP Clinic by The Wellness, doctor-led in Marylebone and Canary Wharf. We offer polynucleotides, PRP and combined regenerative protocols under one roof, so our doctors can recommend the treatment that genuinely suits your under-eye, not just the one we happen to sell. That honesty is why patients trust us with the most delicate area of the face.
Considering polynucleotides for your under-eyes? Message a GMC-registered doctor on WhatsApp or email team@thewellnesslondon.com.
What are polynucleotides and how do they work under the eyes
Polynucleotides are fragments of purified DNA, typically sourced from salmon or trout, that act as a signal to the skin's own repair cells. Injected into the thin skin under the eye, they stimulate fibroblasts, support collagen and elastin production, improve hydration and mop up the free radicals that drive ageing. The result builds gradually as the skin remodels.
This matters under the eye because the skin there is the thinnest on the body, often less than half a millimetre. When it thins further, the bluish vessels and structures beneath show through, which reads as a dark circle. Polynucleotides increase the density of that skin so it becomes a better natural cover. They are best evidenced for under-eye rejuvenation among the regenerative options, which is why they have become the go-to for this specific concern.
Do polynucleotides work for dark circles
For the right type of dark circle, yes. Most under-eye darkness is not actually pigment, it is transparency, where thin skin lets the colour beneath show through. By thickening and improving the quality of the skin, polynucleotides reduce that see-through effect and give a fresher, less shadowed look.
The evidence base is growing rather than settled, and it is right to be honest about that. A split-face randomised study of polynucleotides in the under-eye area reported good safety with no serious adverse events, and clinic data have reported a measurable increase in skin thickness after a short course. Most published studies remain small, so a doctor's assessment of your specific dark circle, whether it is thin skin, pigment, hollowing or a mix, is what determines whether polynucleotides will help you or whether another approach fits better.
Not sure what is causing your dark circles? Ask our doctors on WhatsApp.
Polynucleotides versus PRP under the eyes. Which is better
There is no single winner because they work differently and suit different people. Polynucleotides are a manufactured, CE-marked product with consistent dosing, strong signals for under-eye skin quality and a smooth, predictable course. PRP uses growth factors concentrated from your own blood, which appeals to patients who want a fully autologous treatment using nothing but their own cells.
In practice our doctors often combine them or sequence them. Polynucleotides are usually the first choice where the main issue is thin, crepey under-eye skin. PRP adds growth-factor stimulation and broader rejuvenation and can complement polynucleotides well. Neither treatment adds volume, so if your main concern is a hollow tear trough, a doctor may discuss filler instead or alongside. The advantage of a clinic that offers all of these is that the recommendation is driven by your face, not by what is on the menu.
How many sessions and what is the downtime
Polynucleotides under the eyes are typically given as a short course, often two to three sessions spaced around two weeks apart, with maintenance later. The treatment uses very fine needles with topical anaesthetic, so most patients report only mild discomfort. The procedure itself is quick.
Downtime is minimal. You may have small injection marks, mild swelling or slight bruising for a day or two, which settle quickly. Because polynucleotides work by stimulating your own repair processes, the improvement is progressive rather than instant. Skin looks fresher and feels firmer over the weeks following the course as collagen and elastin rebuild. Your doctor will give you a realistic timeline and aftercare guidance at your consultation.
How much do polynucleotides under eyes cost in London
Doctor-led regenerative under-eye treatment in central London sits in a clear band. Harley Street and Mayfair flagship clinics commonly charge at the higher end for this area. At The London PRP Clinic by The Wellness, single-modality regenerative treatment starts from £395, with combined regenerative protocols from £595, and the exact figure for your plan confirmed at consultation.
This is doctor-performed treatment, not a quick add-on by non-medical staff. The fee reflects a GMC-registered doctor assessing the under-eye properly, performing the treatment in a delicate area, and reviewing your progress. For comparison, our autologous options around the eye and face include PRP facial from £395 and ExoRevive exosome therapy at £445, so your doctor can build the right single or combined approach for your skin within a clear, doctor-led pricing structure.
Why people choose The London PRP Clinic by The Wellness
We are a doctor-led clinic that offers the full regenerative range, so we recommend what suits your under-eye rather than the one product we stock. Across our treatments we report an 87 percent patient success rate and an average density increase of 32 percent in hair restoration, supported by more than 187 five-star reviews. Every treatment is performed by GMC-registered doctors.
For the under-eye, the most delicate area of the face, that combination matters. Having polynucleotides, PRP, exosomes and combined protocols available under one roof means our doctors can tell you honestly which approach, or which mix, will give the best result for your specific concern. We will also tell you when polynucleotides are not the answer for you.
Take the first step today. Message us on WhatsApp, email team@thewellnesslondon.com, or call +44 20 3951 3429. Clinics in Marylebone, two minutes from Baker Street, and Canary Wharf.
Frequently asked questions about polynucleotides under eyes
What are polynucleotides made from?
They are purified DNA fragments, usually derived from salmon or trout, that signal your skin's repair cells to produce more collagen and elastin and to improve hydration. The products used are CE marked.
Are polynucleotides better than filler for dark circles?
They do different jobs. Polynucleotides improve the quality and thickness of thin under-eye skin, while filler adds volume to a hollow tear trough. The best option depends on whether your concern is skin quality or structural hollowing, which a doctor will assess.
How many sessions of polynucleotides do I need under the eyes?
Usually a short course of around two to three sessions spaced about two weeks apart, with maintenance later. Results build progressively over the weeks after the course as the skin remodels.
Is there any downtime?
Minimal. You may have small injection marks, mild swelling or slight bruising for a day or two. Very fine needles and topical anaesthetic keep discomfort low.
Can polynucleotides be combined with PRP?
Yes, and they often are. Polynucleotides target skin quality while PRP adds growth-factor stimulation. Our doctors can combine or sequence them for the best result for your under-eye.
Where in London can I have polynucleotides under eyes?
The London PRP Clinic by The Wellness has doctor-led clinics in Marylebone, two minutes from Baker Street, and Canary Wharf. Message on WhatsApp or call +44 20 3951 3429.
This article is for information and does not replace personal medical advice. Polynucleotide therapy is a medical treatment with a growing but still developing evidence base, and individual results vary. A severe seafood allergy may be a contraindication, which your doctor will check. All treatments at The London PRP Clinic by The Wellness are performed by GMC-registered doctors. Reviewed by the medical team at The London PRP Clinic by The Wellness. Last updated June 2026.
<!-- JSON-LD SCHEMA. Paste into Squarespace page header code injection --> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "MedicalWebPage", "name": "Polynucleotides Under Eyes London. Dark Circles, Crepey Skin And What To Expect", "description": "A GMC-registered doctor explains polynucleotides under eyes in London, how they treat dark circles and crepey skin, how they compare with PRP and filler, sessions and downtime, and what results to expect.", "datePublished": "2026-05-30", "dateModified": "2026-05-30", "inLanguage": "en-GB", "medicalAudience": "https://schema.org/Patient", "about": [ {"@type": "MedicalProcedure", "name": "Polynucleotide skin rejuvenation"}, {"@type": "MedicalProcedure", "name": "Platelet-rich plasma therapy"} ], "mainEntityOfPage": { "@type": "MedicalClinic", "name": "The London PRP Clinic by The Wellness", "medicalSpecialty": "Dermatology", "telephone": "+442039513429", "areaServed": "London", "address": [ {"@type": "PostalAddress", "addressLocality": "Marylebone", "addressRegion": "London", "addressCountry": "GB"}, {"@type": "PostalAddress", "addressLocality": "Canary Wharf", "addressRegion": "London", "addressCountry": "GB"} ], "aggregateRating": {"@type": "AggregateRating", "ratingValue": "5", "reviewCount": "187"} }, "reviewedBy": {"@type": "Organization", "name": "The London PRP Clinic by The Wellness medical team"} } </script> <script type="application/ld+json"> { "@context": "https://schema.org", "@type": "FAQPage", "mainEntity": [ {"@type": "Question", "name": "What are polynucleotides made from?", "acceptedAnswer": {"@type": "Answer", "text": "They are purified DNA fragments, usually derived from salmon or trout, that signal your skin's repair cells to produce more collagen and elastin and to improve hydration. The products used are CE marked."}}, {"@type": "Question", "name": "Are polynucleotides better than filler for dark circles?", "acceptedAnswer": {"@type": "Answer", "text": "They do different jobs. Polynucleotides improve the quality and thickness of thin under-eye skin, while filler adds volume to a hollow tear trough. The best option depends on whether your concern is skin quality or structural hollowing, which a doctor assesses."}}, {"@type": "Question", "name": "How many sessions of polynucleotides do I need under the eyes?", "acceptedAnswer": {"@type": "Answer", "text": "Usually a short course of around two to three sessions spaced about two weeks apart, with maintenance later. Results build progressively over the weeks after the course."}}, {"@type": "Question", "name": "Is there any downtime with polynucleotides under eyes?", "acceptedAnswer": {"@type": "Answer", "text": "Minimal. You may have small injection marks, mild swelling or slight bruising for a day or two. Very fine needles and topical anaesthetic keep discomfort low."}}, {"@type": "Question", "name": "Can polynucleotides be combined with PRP?", "acceptedAnswer": {"@type": "Answer", "text": "Yes, and they often are. Polynucleotides target skin quality while PRP adds growth-factor stimulation. Our doctors can combine or sequence them for the best result for your under-eye."}}, {"@type": "Question", "name": "Where in London can I have polynucleotides under eyes?", "acceptedAnswer": {"@type": "Answer", "text": "The London PRP Clinic by The Wellness has doctor-led clinics in Marylebone, two minutes from Baker Street, and Canary Wharf. Message on WhatsApp or call +44 20 3951 3429."}} ] } </script>