PRP for Joint Pain & Osteoarthritis
Evidence-based platelet-rich plasma therapy for chronic joint pain, osteoarthritis, and mobility restoration
Osteoarthritis affects millions worldwide, causing chronic pain, stiffness, and progressive loss of function. Traditional treatments—pain medications, cortisone injections, physical therapy—offer symptomatic relief but don't address the underlying cartilage degeneration. Surgery remains the ultimate option for advanced cases, but what about those not ready for joint replacement?
At The London PRP Clinic, we offer evidence-based PRP therapy for joint pain and osteoarthritis—a regenerative approach that targets the biological mechanisms of cartilage breakdown while promoting natural healing.
Understanding Osteoarthritis: Beyond Wear and Tear
Osteoarthritis (OA) is more complex than simple "wear and tear." It involves:
Cartilage degradation: Progressive breakdown of the protective cartilage cushioning joint surfaces
Inflammatory cascade: Elevated pro-inflammatory cytokines (IL-1, TNF-α) that accelerate cartilage loss
Synovial membrane changes: Inflammation of the joint lining, contributing to pain and swelling
Subchondral bone alterations: Changes in bone beneath cartilage, including osteophyte (bone spur) formation
Reduced lubrication: Decreased quality and quantity of synovial fluid
The result: pain, stiffness, reduced range of motion, and declining quality of life. OA most commonly affects knees, hips, hands, and spine—areas subject to repetitive stress and weight-bearing loads.
How PRP Treats Joint Pain and Osteoarthritis
Platelet-rich plasma contains concentrated growth factors and bioactive proteins that directly address OA pathophysiology:
Growth Factor Delivery
PDGF (Platelet-Derived Growth Factor): Stimulates chondrocyte (cartilage cell) proliferation and matrix production
TGF-β (Transforming Growth Factor-Beta): Promotes cartilage repair and reduces inflammatory signaling
VEGF (Vascular Endothelial Growth Factor): Enhances nutrient delivery through angiogenesis
IGF-1 (Insulin-Like Growth Factor): Supports cartilage homeostasis and tissue regeneration
Anti-Inflammatory Modulation
PRP downregulates inflammatory cytokines while upregulating anti-inflammatory mediators, creating a joint environment conducive to healing rather than continued degradation.
Cartilage Protection & Repair
Growth factors stimulate remaining chondrocytes to produce new cartilage matrix components (collagen type II, proteoglycans). While PRP cannot regenerate destroyed cartilage, it can slow progression and potentially enhance remaining cartilage quality.
Pain Reduction
Multiple mechanisms contribute to analgesia: reduced inflammation, improved lubrication, modulated pain signaling pathways, and enhanced tissue health.
The Clinical Evidence
Research supporting PRP for osteoarthritis has expanded significantly:
Meta-Analyses & Systematic Reviews
A 2023 systematic review in Frontiers in Medicine analyzed 24 randomized controlled trials comprising 1,344 patients with osteoarthritis. Findings demonstrated that PRP injections provided statistically significant improvement in pain scores and functional outcomes compared to placebo and hyaluronic acid.
A 2025 comprehensive narrative review in Journal of Clinical Medicine examining 40 high-quality studies concluded: "PRP injections—particularly leukocyte-poor PRP—demonstrate superior pain relief and functional improvement compared to hyaluronic acid and corticosteroids, especially in patients with mild to moderate knee OA."
Specific Study Findings
Pain Relief: Multiple studies document clinically meaningful reduction in VAS (Visual Analog Scale) pain scores, with effects typically manifesting within 4-6 weeks and lasting 6-12 months.
Functional Improvement: WOMAC (Western Ontario and McMaster Universities Arthritis Index) scores show significant enhancement in physical function, stiffness, and overall joint health.
Superior to Alternatives: Comparative trials indicate PRP outperforms hyaluronic acid (traditional "gel" injections) and provides longer-lasting relief than corticosteroids without the associated cartilage-damaging effects.
Safety Profile: Adverse events are mild and transient (temporary pain flare-up, minor swelling). No serious complications reported in major trials. No cartilage damage or accelerated degeneration observed.
Important Nuances
Not all research shows dramatic benefits. Some high-quality trials (like the RESTORE study) found no significant difference between PRP and placebo at 12 months in certain populations. This heterogeneity likely reflects:
Variability in PRP preparation methods (concentration, leukocyte content)
Patient selection differences (OA severity, age, BMI)
Injection technique variations
Follow-up duration differences
The consensus: PRP works best for mild-to-moderate OA (Kellgren-Lawrence grades I-III) in carefully selected patients, using optimized leukocyte-poor formulations.
The London PRP Clinic Joint Protocol
Our approach reflects current evidence and clinical best practices:
Advanced PRP Preparation
We utilize pharmaceutical-grade centrifugation systems that produce leukocyte-poor PRP with optimal platelet concentration (4-5x baseline). Research indicates leukocyte-poor formulations provide superior outcomes with fewer inflammatory side effects compared to leukocyte-rich PRP.
Preparation matters enormously. The quality and consistency of PRP directly influences clinical results.
Ultrasound-Guided Injection
Precise delivery is crucial. We use ultrasound guidance to ensure PRP is injected accurately into the joint space, maximizing therapeutic benefit and minimizing discomfort.
Comprehensive Supplement Protocol
Joint health extends beyond injections. We provide evidence-based oral supplements:
Glucosamine & Chondroitin: Long-studied supplements that may support cartilage health and reduce OA progression
Marine Collagen: Provides amino acids essential for connective tissue maintenance
Vitamin D3: Critical for bone health; deficiency associated with worsened OA outcomes
Omega-3 Fatty Acids: Anti-inflammatory properties may complement PRP's effects
This holistic approach mirrors the philosophy guiding our hair and facial treatments—address the condition comprehensively, not in isolation.
Treatment Frequency
Initial protocol typically involves:
1-3 PRP injections spaced 2-4 weeks apart, depending on OA severity
Maintenance injections every 6-12 months to sustain benefits
Ongoing supplement regimen for continuous joint support
Treatment Experience: What to Expect
Initial Assessment
Your consultation includes:
Medical history: Previous treatments, medications, surgical history
Physical examination: Range of motion, pain patterns, joint stability
Imaging review: X-rays or MRI to assess OA severity and appropriateness for PRP
Treatment planning: Personalized protocol based on your specific condition
We assess Kellgren-Lawrence grade (OA severity scale 0-4) to determine candidacy. Grades I-III typically respond well; Grade IV (severe, bone-on-bone) may require surgical consultation.
PRP Injection Session
Blood Collection: Small sample drawn from your arm
Centrifugation: 10-15 minutes to prepare PRP
Joint Preparation: Cleansing and local anesthetic if needed
Ultrasound-Guided Injection: Precise delivery into joint space
Post-injection Care: Brief rest, ice application, activity modifications
The procedure requires approximately 45-60 minutes. Most patients report minimal discomfort—less painful than cortisone injections.
Recovery & Results Timeline
Immediate (0-48 hours): Possible temporary pain flare-up or swelling (manageable with ice and acetaminophen)
Weeks 1-4: Gradual inflammation reduction; some patients report early symptom improvement
Weeks 4-6: Significant pain reduction and functional improvement typically manifest
Months 3-6: Continued enhancement as tissue remodeling progresses
Months 6-12: Sustained benefits; maintenance injection may be scheduled
Individual response varies based on OA severity, age, body weight, activity level, and adherence to complementary care.
Activity Modifications
Post-injection guidelines:
Rest joint for 24-48 hours (avoid strenuous activity)
Ice application for comfort (20 minutes, several times daily)
Gentle range-of-motion exercises after initial rest period
Gradual return to normal activities over 1-2 weeks
Physical therapy often recommended to optimize outcomes
Who Benefits Most from PRP Joint Therapy?
Ideal candidates:
Mild-to-moderate osteoarthritis (Kellgren-Lawrence grades I-III)
Chronic joint pain unresponsive to conservative treatment
Those seeking to delay or avoid surgery
Active individuals wanting to maintain mobility and quality of life
Patients unable to take NSAIDs or seeking non-pharmacological options
Less suitable candidates:
Severe, end-stage OA with complete cartilage loss (bone-on-bone)
Active joint infection
Bleeding disorders or anticoagulation therapy
Rheumatoid arthritis or other inflammatory arthropathies (different pathophysiology)
Your consultation will determine appropriateness based on medical assessment.
Joints We Treat
Knee Osteoarthritis
The most extensively studied application. PRP has robust evidence for knee OA, with numerous trials demonstrating efficacy. The knee's accessible anatomy makes ultrasound-guided injection straightforward and precise.
Hip Osteoarthritis
Emerging evidence supports PRP for hip OA. While studies are fewer than for knee, initial results are promising. Ultrasound guidance is essential given hip anatomy.
Shoulder Pain
Rotator cuff tendinopathy, mild shoulder arthritis, and chronic shoulder pain may benefit from PRP. Evidence is growing for these applications.
Other Joints
Ankle, wrist, and small joint arthritis may respond to PRP, though evidence is more limited. We assess each case individually.
PRP vs. Other Joint Treatments
Corticosteroid Injections
Pros: Rapid pain relief, widely available, inexpensive
Cons: Short duration (weeks to few months), potential cartilage damage with repeated use, suppresses healing
Verdict: PRP provides longer-lasting relief without cartilage-damaging effects
Hyaluronic Acid ("Gel") Injections
Pros: FDA-approved, improve lubrication
Cons: Mixed evidence, effects may be modest, require multiple injections
Verdict: Recent meta-analyses suggest PRP superior to HA for pain and function
Physical Therapy
Pros: Evidence-based, improves strength and mechanics, no injections
Cons: Requires significant time commitment, benefits plateau
Verdict: Excellent complementary therapy; PRP + PT often superior to either alone
Surgery (Joint Replacement)
Pros: Definitive solution for severe OA, long-lasting outcomes
Cons: Major surgery, lengthy recovery, risks, finite implant lifespan
Verdict: Appropriate for end-stage OA; PRP may delay need or improve outcomes if surgery eventually required
Real Patient Outcomes
"I have been taking my mother to the London PRP Clinic for Knee PRP injections over the past year. She previously struggled with significant knee pain, but since receiving treatment, her condition has greatly improved. Her friends recommended this clinic, and it has made a remarkable difference; she can now play with my children and no longer needs to take Ibuprofen daily. I am grateful to the team for their excellent work. She continues to take daily supplements, and her doctor has noted that her joints are in the best condition they have ever been." — Sophia, ★★★★★
Safety, Risks & Contraindications
PRP joint therapy is remarkably safe:
Common, mild effects:
Temporary pain flare-up (24-48 hours post-injection)
Minor swelling or stiffness
Bruising at injection site
Rare complications:
Infection (< 0.1% in clinical trials)
Allergic reaction (extremely rare with autologous product)
Contraindications:
Active joint infection or systemic infection
Blood disorders affecting platelets
Current anticoagulation (relative contraindication; may require medical clearance)
Cancer affecting blood/bone marrow
Investment in Joint Health
Pricing reflects medical expertise, advanced preparation systems, ultrasound guidance, and comprehensive supplements:
Single joint PRP injection: Starting at £600
Package of 3 injections: £1,500 (optimal for moderate OA)
Includes: Complete supplement regimen for 3 months
We offer transparent pricing and honest assessment. If surgery is more appropriate, we'll refer you to an orthopedic specialist.
Why The London PRP Clinic for Joint PRP?
Medical Expertise: Doctor-performed with specialised musculoskeletal training
Ultrasound Guidance: Precise delivery for maximum efficacy and comfort
Leukocyte-Poor PRP: Optimised formulation based on latest evidence
Comprehensive Care: Integrated supplement protocol, not just injections
Evidence-Based Practice: Treatment mirrors published research protocols
Honest Assessment: We won't inject if surgery is more appropriate
Convenient Access: Marylebone, Canary Wharf, Belgravia locations
Regain Mobility and Quality of Life
Joint pain shouldn't define your life. Evidence-based PRP therapy offers a regenerative alternative—addressing the biological causes of osteoarthritis, not merely masking symptoms.
Ready to explore PRP for your joint pain?
Schedule Your Free Joint Assessment on WhatsApp
Our doctors will review your medical history, assess your joint condition, and determine if PRP therapy is the right approach for restoring your mobility and comfort.
Frequently Asked Questions (FAQ)
How effective is PRP for knee osteoarthritis?
Clinical evidence demonstrates PRP provides statistically significant pain relief and functional improvement in mild-to-moderate knee OA. Meta-analyses show PRP outperforms placebo, hyaluronic acid, and corticosteroids for sustained benefit. Approximately 60-70% of appropriately selected patients experience meaningful improvement. Effectiveness depends on OA severity, PRP preparation quality, and patient factors like age, weight, and activity level.
How long does PRP joint injection relief last?
Most patients experience pain relief lasting 6-12 months from a single injection series. Some studies document benefits extending to 18-24 months. Duration varies based on OA severity, patient age/weight, activity level, and adherence to complementary care (supplements, physical therapy). Maintenance injections every 6-12 months sustain benefits.
Is PRP better than cortisone for joint pain?
PRP offers several advantages: longer-lasting relief (months vs. weeks), no cartilage-damaging effects, regenerative rather than purely anti-inflammatory, and better long-term outcomes. Cortisone provides faster initial relief but shorter duration and potential harm with repeated use. For chronic OA, PRP is generally preferred; for acute flare-ups, cortisone may have a role.
Can PRP regenerate lost cartilage?
PRP cannot fully regenerate completely destroyed cartilage—that requires surgical intervention or future stem cell therapies still in development. However, PRP can slow OA progression, enhance the quality of remaining cartilage, stimulate chondrocyte activity, and improve the overall joint environment. It's disease-modifying rather than curative.
How painful is a PRP joint injection?
Most patients report less discomfort than cortisone injections. Ultrasound guidance ensures precise placement, minimizing tissue trauma. We offer local anesthetic if desired. Post-injection soreness is common but typically mild and manageable with ice and acetaminophen. Most patients rate pain as 3-4/10 during injection, improving quickly.
Can I get PRP for hip osteoarthritis?
Yes. Hip OA responds to PRP, though evidence is less extensive than for knee. The hip joint's anatomy requires ultrasound guidance for accurate injection. Initial studies show promising results for pain reduction and functional improvement. Consultation will determine appropriateness based on imaging and examination.
Will my insurance cover PRP for osteoarthritis?
Coverage varies by insurer and policy. Some insurance plans cover PRP for documented OA when conservative treatments have failed; others consider it experimental and exclude coverage. We recommend contacting your insurer beforehand. We provide detailed documentation to support reimbursement claims. Self-pay pricing is transparent.
How many PRP injections do I need for joint pain?
Mild OA may respond to a single injection; moderate OA typically requires 2-3 injections spaced 2-4 weeks apart. Severe OA (Grade III-IV) may need 3 injections but has higher failure rate. After initial series, maintenance injections every 6-12 months sustain benefits. Your treatment plan will be individualized.
What should I avoid after PRP joint injection?
Avoid strenuous activity for 48 hours (let the joint rest). No NSAIDs (ibuprofen, naproxen) for 1-2 weeks as they may interfere with healing. Avoid ice for first 24 hours (may impair platelet activity). Use acetaminophen for discomfort. No swimming pools/hot tubs for 48 hours (infection risk). Gentle range-of-motion exercises are encouraged after initial rest.
Can PRP help me avoid knee replacement surgery?
PRP may delay or potentially avoid surgery for some patients with mild-moderate OA. Studies suggest PRP can provide meaningful symptom relief for years. However, PRP cannot address severe, bone-on-bone arthritis requiring replacement. It's most effective as a bridge therapy for those not ready for surgery or seeking to maximize function before eventual surgery.
Take control of your joint health with evidence-based PRP therapy.
Contact The London PRP Clinic via WhatsApp
The London PRP Clinic | Regenerative Joint Therapy | Marylebone • Canary Wharf • Belgravia
