PRP vs Polynucleotides vs Exosomes How to Choose the Right Regenerative Treatment
Regenerative aesthetics now has three headline treatments, and they are constantly confused with one another. PRP, made by concentrating the platelets in your own blood, polynucleotides, purified DNA fragments that stimulate the skin's own repair and exosomes, the tiny signalling messengers that carry instructions between cells. They overlap, but they are not the same, and they do different jobs, so the right choice depends far less on which is fashionable and far more on your actual goal, whether that is overall skin quality, the delicate under-eye area, thinning hair, scarring, or a combination. The honest position, and the one that gives the best results, is that no single treatment is best at everything, and a good clinic matches the treatment to you rather than selling whichever it prefers. This guide sets out, plainly, what each one is, how they compare, and how to choose between them, so you can walk into a consultation already understanding the options. At The London PRP Clinic by The Wellness in Marylebone, a GMC-registered doctor recommends the right treatment for your goal, and is honest when a cheaper or a different one suits you better. Fees are discussed further down this page.
Medically reviewed by a GMC-registered doctor at The London PRP Clinic by The Wellness. Last updated August 2026.
Message a GMC-registered doctor on WhatsApp or email team@thewellnesslondon.com or call +44 20 3951 3429.
At a glance
PRP, polynucleotides and exosomes are all regenerative treatments that improve skin and hair by prompting the body's own repair, but they work differently and suit different goals, so the right one depends on what you want to achieve, not on which is most talked about.
PRP uses your own blood and is a strong all-rounder for skin quality and hair; polynucleotides excel at hydration, fine lines and delicate areas such as the under-eye; exosomes are the newest and most potent signallers, often used to boost results, though the least regulated.
A doctor-led clinic matches the treatment, or the combination, to your goal and is willing to say when a simpler or cheaper option is the better choice, which is the difference between a considered plan and an upsell.
What each treatment actually is
PRP, platelet-rich plasma, is made by taking a small sample of your blood, spinning it to concentrate the platelets, and injecting that concentrate back into the skin or scalp, where the platelets release growth factors that stimulate repair, collagen and, in the scalp, the hair follicles. Because it comes entirely from you, it carries no risk of allergy or rejection, and it is the most established of the three with the largest body of evidence, particularly for hair and skin quality.
Polynucleotides are short chains of purified DNA fragments, usually derived from salmon or trout, that are injected into the skin, where they support the fibroblasts that build and maintain it, improving hydration, elasticity and texture over a course. They are especially valued for delicate areas, notably the under-eye, and for skin quality and fine lines, and they have become one of the most popular regenerative treatments precisely because they give a natural, gradual improvement.
Exosomes are the newest and, in the laboratory, the most potent of the three: tiny vesicles that carry the signalling molecules cells use to instruct one another, effectively concentrated messages that drive repair. They are typically used to amplify results, often applied after microneedling or alongside other treatments, and they show real promise, but they are also the least standardised and least regulated, which is an honest caveat rather than a dismissal, and a reason to have them only through a doctor-led clinic that knows its source.
How they compare
This is a general comparison to help you understand the options; your personal plan depends on assessment, because the right choice is individual.
PRPPolynucleotidesExosomesWhat it isYour own concentrated plateletsPurified DNA fragmentsCell-signalling messengersBest known forHair, overall skin qualityUnder-eye, hydration, fine linesBoosting results, post-microneedlingFrom your own bodyYesNoNoEvidence baseLargest, most establishedGrowing, strong for skin qualityNewest, most promising but least standardisedTypical course3 sessions, then maintenance2 to 3 sessions, then maintenanceOften added to other treatmentsResults build overWeeks to monthsWeeks to monthsWeeks
The table shows the point: these are complementary tools, not rivals, and choosing between them is about matching the tool to the job.
Which is right for which goal
For hair thinning and early hair loss, PRP has the strongest track record and is usually the starting point, sometimes with exosomes added to boost it. For overall skin quality, tone and a healthy glow, PRP and polynucleotides both work well, and the choice comes down to your skin and preference. For the delicate under-eye area, dark circles and crepey lower lids, polynucleotides are often the treatment of choice because they are gentle and improve skin quality without adding volume. For fine lines, hydration and early ageing, polynucleotides shine, while for scarring and texture, PRP and exosomes with microneedling are commonly used.
The reason this matters is that choosing by reputation rather than goal leads to disappointment, someone books the treatment they have heard most about and finds it was not the best fit for their concern. A proper consultation starts from what you want to improve and works backward to the treatment, or the combination, most likely to achieve it, which is exactly the judgement a doctor-led clinic provides and a treatment menu alone does not.
Not sure which fits your goal? Ask our doctors on WhatsApp or email team@thewellnesslondon.com.
Can they be combined?
Yes, and combining them thoughtfully is often where the best results come from, because each does something the others do less well. PRP or polynucleotides can improve the underlying skin quality while exosomes with microneedling amplify the effect, and across a course a doctor may sequence treatments to build on one another. The key word is thoughtfully: combinations should be planned around your goal and your response, not stacked to inflate a bill.
This is where honesty separates a good clinic from a sales-led one. Sometimes a single treatment is all you need, and being told that, rather than being sold a three-treatment package, is a sign of a clinic worth trusting. A doctor-led approach recommends a combination only where it genuinely adds to the result, and is equally willing to keep the plan simple, which protects both your outcome and your money.
What these treatments cost in London
Regenerative treatment is priced by treatment and by course, and the premium London clinics sit at the top of the market rather than competing on price. As a guide, at The London PRP Clinic by The Wellness a PRP facial is from £395, with microneedling from £495 and with ExoRevive exosome treatment from £695, polynucleotides are from £445 a session, PRP for hair is from £545, and hair exosomes are from £445, with courses at package rates. Pricing aligns with London's leading premium clinics rather than undercutting them, because we compete on outcomes.
Across the market, regenerative treatments span a wide range depending on the clinic and the area treated, and named peers include PRP London Clinic on Cavendish Square, NAR London, Dr David Jack, the Cosmetic Skin Clinic and the established Mayfair clinics. Because all three treatments work as a course with maintenance, the figure that matters is the cost of a completed plan that achieves your goal, not the cheapest single session of whichever treatment you happened to hear about first.
Why people choose The London PRP Clinic by The Wellness
The London PRP Clinic by The Wellness is a doctor-led clinic and one of London's leading choices for regenerative skin and hair treatment. A GMC-registered doctor assesses your goal and recommends the treatment, or the combination, most likely to achieve it, drawing on all three rather than defaulting to the one the clinic prefers to sell. Every doctor on the team has performed at least 100 regenerative and PRP sessions and completed six or more months of clinical surgical training, treatment integrates with primary care at The Wellness, and across our work we report more than 187 five-star reviews.
For a field this full of hype, the service is honesty: what each treatment can and cannot do, which fits your goal, when to combine and when to keep it simple, and when a cheaper option is the right one. Care is available in English, Arabic, Spanish, French and Dutch.
Frequently asked questions about PRP, polynucleotides and exosomes
What is the difference between PRP, polynucleotides and exosomes? PRP uses your own concentrated platelets, polynucleotides are purified DNA fragments that improve skin quality, and exosomes are cell-signalling messengers used to boost results. They work differently and suit different goals, so the right one depends on what you want to achieve.
Which is best for under-eyes? Polynucleotides are often the treatment of choice for the delicate under-eye area, because they improve skin quality and hydration gently without adding volume. A doctor confirms suitability after assessment.
Which is best for hair? PRP has the strongest track record for hair thinning and is usually the starting point, sometimes with exosomes added to boost the effect. A doctor advises based on your hair loss.
Can I combine them? Yes, and a planned combination often gives the best results, because each does something the others do less well. Combinations should be matched to your goal and response rather than stacked to inflate a package.
Which is the most proven? PRP has the largest and most established evidence base, polynucleotides have a growing and strong evidence base for skin quality, and exosomes are the newest and most promising but least standardised, which is why they should be used through a doctor-led clinic.
Book your consultation today
Take the first step today. Message us on WhatsApp, email team@thewellnesslondon.com, or call +44 20 3951 3429.
In person: The London PRP Clinic by The Wellness, 22 Seymour Street, Marylebone, London W1H 7HY. Opening hours Monday to Friday 8am to 8pm, Saturday 9am to 5pm.
This article is for information and does not replace personal medical advice. Regenerative treatments vary in evidence, exosomes being the newest and least standardised, and results vary between individuals. All treatments at The London PRP Clinic by The Wellness are performed by GMC-registered doctors. Reviewed by a GMC-registered doctor, The London PRP Clinic by The Wellness. Last updated August 2026.
References. Published literature on platelet-rich plasma, polynucleotides and exosomes in skin and hair regeneration. British Association of Dermatologists patient information on injectable and regenerative skin treatments. Published 2026 London pricing for regenerative aesthetic treatments.
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