Salmon DNA & Polynucleotide Treatments
How cutting-edge polynucleotide therapy is transforming aesthetic medicine with biocompatible DNA fragments
In the rarefied world of advanced aesthetics, one treatment has captured the attention of dermatologists, researchers, and discerning patients alike: polynucleotide therapy. Also known as PDRN (polydeoxyribonucleotide) or salmon DNA treatment, this revolutionary approach harnesses the regenerative properties of purified DNA fragments to rejuvenate skin at the cellular level.
At The London PRP Clinic, we offer evidence-based polynucleotide treatments as part of our comprehensive regenerative medicine portfolio—because true beauty stems from genuine biological enhancement, not superficial intervention.
Understanding Polynucleotide Therapy
Polynucleotides are chains of nucleotides—the fundamental building blocks of DNA. In aesthetic medicine, we utilize highly purified DNA fragments extracted from salmon or trout sperm, which possess remarkable structural similarity to human DNA. This biocompatibility allows the human body to recognize and integrate these molecules without triggering inflammatory or allergic responses.
The science is elegant: when polynucleotides are introduced into skin tissue, they activate specific cellular receptors—particularly the adenosine A2A receptor on fibroblast cells. This activation initiates a cascade of regenerative processes:
Collagen synthesis acceleration: Fibroblasts increase production of Types I and III collagen, the structural proteins essential for skin firmness
Angiogenesis promotion: Formation of new blood vessels enhances nutrient and oxygen delivery to tissues
Anti-inflammatory modulation: Reduction of inflammatory cytokines creates an optimal environment for healing
DNA repair activation: The salvage pathway recycles nucleotides for cellular repair rather than energy-intensive de novo synthesis
The Clinical Evidence
Published research demonstrates the therapeutic potential of polynucleotide therapy across multiple aesthetic applications:
A study in Dermatologic Surgery (2024) confirmed that polynucleotides target the adenosine A2A receptor and salvage pathway to promote skin regeneration. Clinical trials document improvements including:
60% increase in collagen production
22% enhancement in skin elasticity
15% improvement in hydration levels
Visible reduction in fine lines and wrinkles
More even skin tone and refined texture
The evidence extends beyond facial aesthetics. Research published in multiple journals indicates polynucleotides effectively address scarring, photoaging, stretch marks, and even hair loss when combined with complementary therapies.
Polynucleotides vs. Traditional Injectables
Unlike conventional dermal fillers that merely add volume or neuromodulators that temporarily relax muscles, polynucleotide therapy works at a fundamentally different level:
Mechanism: Genuine tissue regeneration versus temporary augmentation
Longevity: Results improve progressively over months as new collagen develops, lasting 12+ months
Natural outcomes: Enhances your skin's inherent quality rather than creating artificial fullness
Versatility: Suitable for delicate areas (under-eyes, neck, décolletage) where fillers pose higher risk
Safety profile: Biocompatible, minimal adverse effects, no risk of vascular occlusion
Think of traditional fillers as temporary scaffolding—polynucleotides rebuild the actual structure.
Treatment Areas & Applications
Facial Rejuvenation
Polynucleotide therapy excels at addressing:
Fine lines and wrinkles, particularly around the eyes and mouth
Skin laxity and loss of elasticity
Dull, uneven skin tone
Large pores and rough texture
Sun damage and photoaging
Post-inflammatory hyperpigmentation
The treatment is especially valuable for the periocular region (around eyes), where traditional fillers may migrate and Botox has limited application. Polynucleotides safely improve this delicate area by enhancing tissue quality itself.
Neck & Décolletage
These often-neglected areas betray age through crepey texture and fine wrinkles. Polynucleotide therapy restores skin integrity, hydration, and firmness—delivering results that complement facial rejuvenation for harmonious aesthetic improvement.
Scalp & Hair Health
When combined with PRP therapy, polynucleotides enhance blood flow to hair follicles and improve nutrient delivery. This synergistic approach addresses hair thinning and loss more comprehensively than either treatment alone.
Scar Improvement
Polynucleotides promote tissue remodeling, making them effective for improving the appearance of acne scars, surgical scars, and stretch marks. The treatment stimulates organized collagen deposition for smoother, more even skin texture.
The Treatment Protocol
Initial Assessment
Your journey begins with a thorough consultation. Our medical doctors evaluate your skin quality, discuss aesthetic goals, review medical history, and determine whether polynucleotide therapy aligns with your needs. Honesty guides our recommendations—if an alternative approach would serve you better, we'll say so.
Treatment Session
The procedure is remarkably straightforward:
Cleansing: Treatment area is thoroughly cleansed
Numbing (optional): Topical anesthetic cream for comfort
Injection technique: Fine needles deliver polynucleotides in strategic micro-injections across the treatment zone
Post-treatment care: Cooling mask or gentle skincare to soothe skin
Sessions typically require 30-45 minutes. Most patients describe the sensation as minor pinpricks rather than painful—considerably more comfortable than many aesthetic procedures.
Recommended Course
Optimal results require a series of treatments:
Initial phase: 3 sessions spaced 2-4 weeks apart
Maintenance: Touch-up treatments every 6-9 months
Timeline: Initial improvements visible within 2-3 weeks; optimal results develop over 2-3 months as collagen production accelerates
The gradual timeline reflects genuine biological change—your skin is actually improving, not simply appearing better through temporary camouflage.
Combining Treatments for Enhanced Results
Polynucleotide therapy integrates beautifully with complementary treatments:
With PRP: The combination amplifies regenerative signaling—PRP delivers growth factors while polynucleotides enhance cellular receptivity and DNA repair
With Microneedling: Controlled micro-injuries enhance polynucleotide absorption and stimulate additional collagen production
With Medical-Grade Skincare: Retinoids, vitamin C, and peptides work synergistically to support the enhanced cellular activity polynucleotides initiate
With Profhilo: While both are bioremodeling treatments, they work through different mechanisms—combined protocols offer comprehensive skin quality enhancement
Our doctors design integrated treatment plans that maximize results while respecting your skin's capacity for change.
Safety, Side Effects & Contraindications
Polynucleotide therapy boasts an excellent safety profile. The purification process removes proteins that could trigger allergic reactions, leaving only the DNA fragments.
Common, temporary effects:
Mild redness at injection sites (resolves within hours)
Minor swelling (subsides within 24-48 hours)
Slight bruising (uncommon, fades within days)
Temporary firmness or small bumps at injection points
Contraindications include:
Fish or seafood allergy (though purification reduces risk substantially)
Active skin infection or inflammation
Pregnancy or breastfeeding
Autoimmune conditions affecting skin
Current isotretinoin (Accutane) use
Post-treatment guidelines:
Avoid intensive exercise for 24-48 hours
No saunas, steam rooms, or heavy sun exposure for several days
Refrain from other facial treatments for at least one week
Avoid blood-thinning medications/supplements unless medically necessary
Our medical team provides comprehensive aftercare instructions tailored to your treatment.
Polynucleotides: A Sustainable Approach
One often-overlooked advantage: sustainability. The salmon DNA used in polynucleotide therapy typically comes from sustainably farmed fish in European freshwater facilities. Rigorous purification processes ensure medical-grade quality while maintaining environmental responsibility—a consideration that aligns with the values of informed, conscientious patients.
Why The London PRP Clinic for Polynucleotide Therapy?
Medical Expertise: Treatments performed exclusively by qualified doctors trained in regenerative medicine
Advanced Formulations: We utilize premium European-sourced polynucleotide preparations with proven clinical efficacy
Integrated Protocols: Polynucleotide therapy offered as part of comprehensive treatment plans, never in isolation
Evidence-Based Practice: Our approach is grounded in peer-reviewed research, not aesthetic trends
Personalized Care: Treatment plans designed for your unique skin type, concerns, and goals
Transparent Communication: Clear explanations of what polynucleotides can and cannot achieve—we manage expectations honestly
Investment & Pricing
Polynucleotide treatments reflect the advanced nature of this therapy, starting at approximately £390 per region. Treatment packages for multiple sessions offer better value and align with evidence-based protocols for optimal results.
We believe in transparent pricing and never pressure patients toward unnecessary procedures. Your investment should yield meaningful, lasting improvement.
Begin Your Polynucleotide Journey
The London PRP Clinic serves London from convenient locations in Marylebone, Canary Wharf, and Belgravia. We offer flexible scheduling seven days a week, with consultations typically available within 24-48 hours.
Discover how polynucleotide therapy can transform your skin quality from within.
Book Your Free Consultation via WhatsApp
Our medical team is ready to assess your skin, answer your questions, and design a regenerative treatment protocol that delivers genuine, measurable improvement.
Frequently Asked Questions (FAQ)
What exactly is salmon DNA, and why is it used in skincare?
Salmon DNA refers to polydeoxyribonucleotides (PDRN) extracted from salmon or trout sperm. These DNA fragments share remarkable structural similarity with human DNA, making them highly biocompatible. When introduced into skin, they activate cellular repair mechanisms, stimulate collagen production, reduce inflammation, and promote new blood vessel formation. The result: genuine tissue regeneration rather than superficial enhancement.
How is polynucleotide therapy different from PRP or Profhilo?
While all three are regenerative treatments, they work through distinct mechanisms. PRP uses your own platelet-derived growth factors; polynucleotides utilize DNA fragments to activate specific cellular receptors; Profhilo employs high-concentration hyaluronic acid for bio-remodeling. They complement each other beautifully—many patients benefit from combined protocols that leverage multiple regenerative pathways simultaneously.
Will I see immediate results from polynucleotide treatment?
Polynucleotide therapy produces gradual, progressive improvement as your skin generates new collagen and tissue. Initial changes often appear within 2-3 weeks (improved hydration, subtle glow), but optimal results develop over 2-3 months. This timeline reflects genuine biological change. Patients seeking instant transformation may prefer traditional fillers; those valuing authentic improvement appreciate polynucleotides' natural progression.
How long do polynucleotide results last?
Effects typically persist 9-12 months, sometimes longer. Because the treatment stimulates your body's own collagen production, results can be maintained with periodic touch-up sessions (every 6-9 months). The longevity surpasses many traditional injectables while appearing completely natural—a key advantage for discerning patients.
Is polynucleotide treatment painful?
Most patients report minimal discomfort. We apply topical numbing cream before treatment, and the injections use ultra-fine needles. Patients typically describe a series of small pinpricks rather than significant pain. Post-treatment tenderness is mild and short-lived. Overall, polynucleotide therapy is considerably more comfortable than many aesthetic procedures.
Can polynucleotides treat under-eye hollows and dark circles?
Polynucleotides excel in the periocular (eye) area, where they improve skin quality, hydration, and fine lines. However, they don't add volume like fillers do. For true structural hollows, a combination approach may be recommended—polynucleotides to enhance tissue quality, with conservative filler for volume if needed. Dark circles caused by pigmentation or poor circulation may improve as polynucleotides enhance vascular health and skin thickness.
I have sensitive skin—is this treatment suitable for me?
Polynucleotide therapy is particularly well-suited to sensitive skin due to its anti-inflammatory properties. The treatment actually helps calm irritation and strengthen the skin barrier. However, if you have active rosacea, eczema, or dermatitis, we recommend treating these conditions first. Your consultation will include a thorough skin assessment to ensure appropriateness and safety.
Do I need to avoid any activities after polynucleotide treatment?
Post-treatment restrictions are minimal but important: avoid intensive exercise for 24-48 hours, skip saunas/steam rooms for several days, limit sun exposure and use SPF diligently, don't schedule other facial treatments for at least one week, and avoid blood-thinning supplements unless medically necessary. You can return to work and normal activities immediately, though some patients prefer scheduling treatments on Friday for weekend recovery from any minor swelling.
Can polynucleotide therapy be combined with Botox or fillers?
Absolutely. Many patients benefit from a comprehensive aesthetic approach: Botox addresses dynamic wrinkles from muscle movement, fillers restore volume loss, and polynucleotides enhance overall skin quality. We typically recommend spacing treatments appropriately (2+ weeks between different procedures) to allow proper healing and avoid confounding results. Your treatment plan will outline optimal timing.
How many sessions do I need to see results?
Evidence-based protocols recommend 3 treatment sessions spaced 2-4 weeks apart for optimal results. Some patients with severe photo-damage or advanced aging may benefit from 4 sessions. After the initial course, maintenance treatments every 6-9 months sustain results. Individual needs vary based on age, skin condition, lifestyle factors, and aesthetic goals—your doctor will provide personalized recommendations.
Experience the future of aesthetic medicine with evidence-based polynucleotide therapy.
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The London PRP Clinic | Advanced Regenerative Aesthetics | Marylebone • Canary Wharf • Belgravia
