How EZ Gel Works: The Science Behind Natural Bio-Filler
How EZ Gel Works: The Science Behind Natural Bio-Filler
Your body already has everything it needs to repair and rejuvenate skin. EZ Gel simply concentrates those healing signals and delivers them exactly where they're needed most.
What Is EZ Gel?
EZ Gel is an autologous bio-filler created by combining two components from your own blood: albumin-rich plasma and platelet-rich fibrin (PRF). Unlike synthetic fillers made from hyaluronic acid, EZ Gel contains no foreign substances—just your body's natural growth factors and proteins.
The preparation involves heating human serum albumin to approximately 75°C, which causes the protein structure to expand and create a gel-like consistency. This is then mixed with liquid PRF in a 2:1 ratio, creating a smooth, injectable material that integrates naturally with your tissue.
The Dual Mechanism: Volume Plus Regeneration
What makes EZ Gel different from traditional fillers is its dual action. Clinical research demonstrates two distinct benefits:
Immediate volumisation – The gel physically fills hollows, smoothing nasolabial folds, under-eye hollows, and areas of volume loss. Research shows patients experience visible improvement within days.
Progressive biostimulation – Growth factors including VEGF, PDGF-BB, TGF-beta, and FGF2 are released over weeks, triggering your body to produce new collagen, elastin, and healthy tissue. This means results actually improve over time rather than simply degrading.
What the Research Shows
A 24-week clinical study tracked patients with moderate-to-severe nasolabial folds who received EZ Gel treatments. The results were significant:
92.3% of patients showed visible improvement by week 20
Wrinkle Severity Rating Scale scores decreased from 3.3 (moderate-severe) to 0.75 (mild)
46% reported being "very much improved" at the 6-month mark
Side effects were limited to mild, temporary swelling
Another study focusing on injectable PRF for facial rejuvenation found significant improvements in skin surface spots and pores at 3-month follow-up, with patients reporting high satisfaction across multiple facial assessment scales.
Why Albumin and PRF Work Together
Human serum albumin makes up nearly 60% of blood plasma proteins and provides structural stability when heated. PRF, meanwhile, contains a concentrated mesh of platelets, white blood cells, and fibrin that acts as a scaffold for tissue regeneration.
Research confirms that combining these elements produces superior outcomes compared to PRF or albumin alone. Studies show EZ Gel achieves:
Better structural stability than conventional PRF
Enhanced growth factor release
Increased alkaline phosphatase activity (a marker of tissue healing)
Higher expression of collagen-stimulating genes
How Long Do Results Last?
The immediate volumising effect lasts 3-6 months as your body naturally absorbs the gel. However, the collagen and tissue regeneration triggered during this period can persist for 12-18 months or longer.
This is why treatment protocols typically involve 3 sessions spaced 4-6 weeks apart—each session builds on the previous one, creating cumulative collagen "stacking" that extends overall durability.
Ready to Discover Your Results?
Understanding the science is the first step. The real transformation happens when you experience it firsthand.
Contact us on WhatsApp to book your consultation
We'll answer your questions, assess your skin, and design a personalised protocol tailored to your goals.
Frequently Asked Questions
Can you combine EZ Gel with HA fillers?
Yes. Some patients use HA for structural volume in areas like cheeks, then add EZ Gel for skin quality and subtle volume in delicate areas like under-eyes.
Is EZ Gel approved?
EZ Gel falls under autologous blood product regulations. Because it uses your own blood components, it doesn't require the same regulatory pathway as synthetic fillers.
How long is the consultation?
Your initial consultation is typically 20-30 minutes. We'll assess your skin, discuss your goals, and answer all your questions before recommending a treatment plan.
Ready to Restore Your Natural Glow?
You don't need to change your face to love it again. You just need to renew it.
The BioRenew Protocol combines the latest regenerative medicine with personalised care. Our clinicians will assess your unique skin and design a treatment plan that works for your goals.
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