PRF and EZ Gel: Understanding Growth Factors in Facial Rejuvenation
PRF and EZ Gel: Understanding Growth Factors in Facial Rejuvenation
Your blood contains powerful healing signals that can regenerate skin, stimulate collagen, and reverse visible signs of ageing. Here's the science behind how PRF and EZ Gel harness this biological potential.
What Are Growth Factors?
Growth factors are proteins that act as chemical messengers, telling your cells to repair, multiply, and regenerate. They're naturally concentrated in platelets—the component of blood responsible for healing wounds.
When you're injured, platelets rush to the site and release growth factors that trigger:
Blood vessel formation (angiogenesis)
Collagen and elastin production
Cell migration and proliferation
Tissue remodelling
PRF and EZ Gel concentrate these same healing signals and deliver them precisely where facial rejuvenation is needed.
The Key Growth Factors in PRF
Research has identified several critical growth factors in platelet-rich fibrin:
PDGF (Platelet-Derived Growth Factor)
Stimulates fibroblast proliferation
Promotes collagen synthesis
Enhances wound healing and tissue repair
TGF-β (Transforming Growth Factor Beta)
Triggers collagen and elastin production
Regulates inflammation and immune response
Promotes tissue regeneration
VEGF (Vascular Endothelial Growth Factor)
Stimulates new blood vessel formation
Improves oxygen and nutrient delivery to skin
Enhances skin vitality and colour
FGF-2 (Fibroblast Growth Factor 2)
Accelerates cell proliferation
Improves tissue integration
Supports long-term regeneration
Studies show liquid PRF produces significantly higher levels of these growth factors compared to traditional PRP, particularly TGF-β, collagen 1, and fibronectin.
How EZ Gel Amplifies Growth Factor Activity
EZ Gel combines PRF with heated albumin plasma, creating a unique advantage over PRF alone:
Sustained Release
The albumin gel acts as a controlled-release matrix, allowing growth factors to be delivered gradually over weeks rather than days. This extends the regenerative signalling period.
Enhanced Structural Stability
Research shows EZ Gel demonstrates better structural stability than conventional PRF, meaning growth factors remain active longer in tissue.
Increased Alkaline Phosphatase Activity
Day-one measurements show higher alkaline phosphatase (a marker of healing) in EZ Gel compared to PRF alone, indicating a more robust early healing response.
What This Means for Your Skin
When growth factors from EZ Gel are injected into facial tissue, they trigger a cascade of biological responses:
Week 1-2: Inflammation and Cell Recruitment
Growth factors signal inflammatory cells and fibroblasts to migrate to the treatment site. This is why you may experience mild swelling initially—it's actually your healing response activating.
Week 3-8: Collagen Synthesis
TGF-β and PDGF stimulate fibroblasts to produce new collagen and elastin fibres. Studies using ultrasound imaging document measurable increases in skin density during this period.
Week 8-24: Tissue Remodelling
New collagen matures and organises into functional tissue. Blood vessel formation improves circulation and skin vitality. Clinical trials show this phase produces the most visible improvement.
The Evidence: What Studies Prove
Collagen Production
A study measuring gene expression after PRF treatment found significant increases in collagen 1 and fibronectin mRNA levels—the genetic signals for collagen production.
Skin Thickness
High-frequency ultrasound measurements documented a 5.08-fold increase in periorbital skin density after three EZ Gel treatments.
Wrinkle Reduction
Multiple studies report significant improvement in deep, fine, and small wrinkles following PRF-based treatments, with effects lasting 6-12 months.
Patient Satisfaction
Validated facial assessment scales show significant improvements in satisfaction with skin quality, facial appearance, and overall contentment with results.
Why PRF Is Superior to PRP
While both contain growth factors, PRF offers distinct advantages:
Higher Growth Factor Concentration
Low-speed centrifugation used for PRF preserves more platelets and white blood cells compared to PRP's high-speed processing.
Sustained Release
PRF's fibrin matrix releases growth factors gradually over 7-14 days, while PRP releases them within 24-48 hours.
Enhanced Cell Migration
Studies show PRF increases skin fibroblast migration by over 350% compared to control groups—meaning cells are more actively recruited to regenerate tissue.
Safety of Growth Factor Therapy
Because PRF and EZ Gel use your own blood components, there's no risk of allergic reaction or disease transmission. Clinical studies spanning hundreds of patients report no serious adverse events related to growth factor activity.
The growth factors in PRF are identical to those your body produces naturally—you're simply concentrating and redirecting them for therapeutic benefit.
Experience Biology-Backed Rejuvenation
Understanding the science is fascinating. But experiencing the results is transformational.
Learn how PRF and EZ Gel can rejuvenate your skin
Our clinicians will explain exactly how growth factors will work for your unique skin, and design a personalised protocol to maximise your results.
Frequently Asked Questions
Can growth factors cause uncontrolled cell growth?
No. The growth factors in PRF signal controlled, organised tissue regeneration, not abnormal cell proliferation. Multiple safety studies confirm no increased cancer risk.
How is PRF different from stem cell therapy?
PRF doesn't contain stem cells—it contains growth factors that signal your existing cells to regenerate. It's simpler, safer, and doesn't require stem cell extraction or culturing.
Do results vary between patients?
Yes. Younger patients with better baseline platelet counts tend to respond more robustly. Smoking, poor nutrition, and certain medications can reduce growth factor efficacy.
Can I use PRF on other areas besides my face?
Yes. PRF has demonstrated benefits for hair loss, joint pain, and other areas. Ask our clinicians about comprehensive regenerative medicine options.
How often should I have EZ Gel treatment?
The standard protocol is 3 sessions spaced 4-6 weeks apart, followed by maintenance treatments every 12-18 months to sustain collagen stacking.
Ready to Restore Your Natural Glow?
You don't need to change your face to love it again. You just need to renew it.
The BioRenew Protocol combines the latest regenerative medicine with personalised care. Our clinicians will assess your unique skin and design a treatment plan that works for your goals.
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