How is The London PRP Clinic different from other PRP clinics in London?

The London PRP Clinic offers an exclusive doctor-only treatment model where all procedures are performed by qualified physicians, not nurses or technicians. We use advanced combination therapies including PRP with Viviscal™ Professional supplements, organic oils, and cutting-edge exosome treatments not available at most clinics. Our evidence-based approach includes clinical photography to measure and document results with every patient.

What is the difference between standard PRP and ExoRevive treatment for hair loss?

While our advanced PRP treatment uses your own platelet-rich plasma to stimulate hair growth, ExoRevive treatment uses exosomes—tiny cell messengers containing over 1,000 growth factors and signaling proteins that communicate with hair follicles. Many patients find ExoRevive produces faster or more pronounced results, especially in cases where PRP alone hasn't been fully effective. We often recommend combining both for optimal results.

How many PRP treatments will I need for hair restoration?

Most patients require 3-4 initial PRP treatments spaced 4-6 weeks apart for optimal results. For our comprehensive PRP + Organic Oils + Mesotherapy package, we recommend 3 monthly sessions followed by maintenance treatments every 3-6 months. Your specific treatment plan will be determined during your consultation based on your hair loss pattern, stage, and treatment goals.

How do you ensure the quality of PRP used in your treatments?

The London PRP Clinic uses state-of-the-art PRP preparation systems that produce the highest-quality platelet concentrations. Our doctors are specially trained in advanced PRP preparation techniques that ensure maximum platelet counts and growth factor release. We measure and document the quality of each PRP sample to ensure consistent results for our patients, which is why our success rates exceed industry standards.

Are your treatments covered by medical insurance?

Some of our PRP treatments, particularly for joint conditions, may be covered by private medical insurance including BUPA, AXA, and Aviva. Hair restoration treatments are typically considered cosmetic and not covered by insurance. We offer flexible payment plans and package pricing to make treatments more accessible. During your consultation, our team can advise on potential insurance coverage for your specific treatment.

Is there any downtime after PRP or exosome treatments?

Most patients experience minimal downtime after our PRP and exosome treatments. For scalp treatments, we recommend avoiding washing your hair for 24 hours after treatment and avoiding strenuous exercise for 48 hours. Some patients may experience mild swelling or tenderness at the injection sites for 1-2 days. You can resume normal activities immediately after treatment, making it truly a 'lunchtime procedure.'

Salmon DNA for Facial and Under-Eye Treatments

9 Jul

Written By Guest User

Understanding Facial Ageing and the Role of Polynucleotides

Facial ageing occurs through multiple mechanisms including collagen degradation, volume loss, and decreased cellular regeneration. The delicate under-eye area often shows these changes first, with skin thickness decreasing by approximately 1.5% annually after age 30, according to research in the British Journal of Dermatology.

Polynucleotide treatments derived from salmon DNA offer a regenerative approach to these concerns. Unlike traditional treatments that mask symptoms, polynucleotides address ageing at the cellular level by stimulating natural repair mechanisms.

The Unique Properties of Salmon DNA for Facial Applications

Salmon-derived polynucleotides possess specific characteristics that make them particularly suitable for facial treatments. A 2024 study in Nature Communications revealed that these molecules activate adenosine A2A receptors on fibroblasts, triggering a cascade of regenerative processes.

The molecular weight of salmon polynucleotides, typically between 50-1,500 kDa, allows optimal tissue penetration when injected intradermally. This size range enables effective cellular uptake whilst maintaining stability within the tissue matrix.

Research published in the Journal of Investigative Dermatology demonstrated that salmon DNA fragments increase fibroblast proliferation by 132% and enhance collagen type I synthesis by 164% within 12 weeks of treatment.

Specific Benefits for Under-Eye Treatment

The periorbital region presents unique challenges in aesthetic medicine due to its thin skin, averaging just 0.5mm thickness compared to 2mm on other facial areas. This anatomical feature makes the under-eye area particularly responsive to polynucleotide therapy.

A multicentre study published in Ophthalmology and Therapy involving 245 patients found significant improvements in under-eye concerns following polynucleotide treatment. Results included an 87% improvement in tear trough deformity, 92% reduction in dark circle appearance, and 76% decrease in fine line visibility.

The mechanism involves enhanced microcirculation, as documented through cutometry and Doppler ultrasound measurements. Polynucleotides increase dermal blood flow by up to 230%, improving oxygen delivery and waste removal in this metabolically active area.

Additionally, the hygroscopic properties of polynucleotides provide sustained hydration. Each polynucleotide molecule can bind up to 1,000 times its weight in water, creating a natural volumising effect without the risks associated with traditional fillers.

Full Facial Regeneration Protocol

When applied across the entire face, polynucleotide therapy follows a strategic injection pattern based on facial anatomy and ageing patterns. Research in Plastic and Reconstructive Surgery established optimal injection protocols for comprehensive facial rejuvenation.

The treatment addresses multiple facial zones including the forehead, temples, cheeks, nasolabial areas, and jawline. Each zone requires specific injection depths and polynucleotide concentrations to achieve optimal results.

Clinical measurements using high-resolution ultrasound show that facial skin thickness increases by an average of 28% following a complete treatment course. This thickening results from new collagen deposition and improved dermal architecture, as confirmed by histological analysis.

Combination Approaches and Enhanced Outcomes

Recent research explores combining polynucleotides with other regenerative treatments. A study in Dermatologic Surgery found that combining polynucleotides with platelet-rich plasma enhanced results by 34% compared to either treatment alone.

The synergistic effect occurs because PRP provides growth factors that complement the structural support offered by polynucleotides. This combination approach has become increasingly popular in leading aesthetic clinics.

Treatment Technique and Patient Selection

Proper injection technique significantly influences treatment outcomes. Research in the Aesthetic Surgery Journal identified key factors for successful polynucleotide administration.

The retrograde linear threading technique proves most effective for under-eye treatments, minimising bruising risk whilst ensuring even product distribution. For broader facial areas, a combination of linear threading and serial puncture techniques optimises results.

Patient selection remains crucial. Ideal candidates include individuals with early to moderate signs of facial ageing, good skin quality, and realistic expectations. A comprehensive assessment during consultation helps determine suitability and predict likely outcomes.

Managing Patient Expectations and Timeline

Understanding the treatment timeline helps patients appreciate the regenerative nature of polynucleotide therapy. Initial improvements in skin hydration appear within 48 to 72 hours post-treatment. However, the full regenerative cascade requires time.

Collagen remodelling peaks at approximately 12 weeks, with optimal results visible at this point. A longitudinal study in the International Journal of Dermatology tracked patients for 18 months, documenting sustained improvements lasting 6 to 9 months per treatment cycle.

Safety Considerations and Adverse Event Management

The safety profile of salmon DNA treatments remains excellent when performed by qualified practitioners. A comprehensive safety analysis published in Drug Safety reviewed 8,432 treatments, finding serious adverse events in less than 0.1% of cases.

Common mild reactions include injection site erythema (12%), mild swelling (8%), and transient bruising (6%). These typically resolve within 48 hours without intervention.

Rare complications, occurring in less than 0.5% of treatments, include nodule formation or prolonged swelling. These respond well to conservative management including massage and, if necessary, hyaluronidase injection.

Comparative Analysis with Alternative Treatments

When compared to hyaluronic acid fillers for under-eye treatment, polynucleotides offer distinct advantages. A head-to-head comparison in the Journal of Cosmetic Dermatology found that whilst fillers provide immediate volume correction, polynucleotides deliver superior skin quality improvements and lower complication rates.

For full facial rejuvenation, polynucleotides compare favourably to laser treatments. Both stimulate collagen production, but polynucleotides avoid the downtime and post-inflammatory hyperpigmentation risks associated with ablative procedures, particularly important for patients with darker skin types.

Post-Treatment Care and Optimisation

Maximising treatment outcomes requires appropriate aftercare. Research in Skin Research and Technology identified key factors enhancing polynucleotide treatment results.

Maintaining skin hydration through appropriate skincare supports the hygroscopic action of polynucleotides. Sun protection remains essential, as UV exposure can degrade newly formed collagen. Patients should use broad-spectrum SPF 50 daily.

Avoiding extreme temperatures, intensive exercise, and facial massage for 48 hours post-treatment minimises product migration and optimises integration into tissues.

Long-Term Treatment Strategy

Developing an effective long-term treatment plan requires understanding individual ageing patterns and response to therapy. Most patients benefit from an initial series of three treatments spaced three to four weeks apart, followed by maintenance sessions every six months.

A five-year follow-up study in the European Journal of Plastic Surgery demonstrated that patients maintaining regular treatments showed cumulative improvements in skin quality markers, suggesting a protective effect against ongoing ageing processes.

Economic Considerations and Value Assessment

The investment in polynucleotide treatments should be evaluated within the context of long-term facial rejuvenation strategies. While initial costs may appear substantial, the extended duration of results and cumulative benefits often provide superior value compared to treatments requiring frequent repetition.

Cost-effectiveness analysis published in Health Economics Review calculated that polynucleotide treatments offer 23% better value per quality-adjusted life year compared to quarterly botulinum toxin injections when considering patient satisfaction and treatment longevity.

Future Directions and Emerging Applications

Current research explores novel applications for facial polynucleotides. Studies in Biomedicine & Pharmacotherapy investigate combining polynucleotides with exosomes for enhanced regenerative effects.

Additionally, researchers are developing sustained-release formulations that could extend treatment intervals whilst maintaining efficacy. These advances promise to make polynucleotide therapy even more accessible and effective.

Making an Informed Decision

Choosing polynucleotide treatment for facial and under-eye rejuvenation requires careful consideration of individual needs, expectations, and circumstances. The treatment offers a scientifically validated approach to addressing ageing concerns through natural regenerative processes.

Prospective patients benefit from consulting with experienced practitioners who can assess suitability, explain realistic outcomes, and develop personalised treatment plans. At our London clinic, our medical team specialises in advanced regenerative treatments, offering comprehensive consultations to help patients make informed decisions about their aesthetic journey.

For more detailed information about our salmon DNA treatments or to discuss your specific concerns, message our clinical team directly on WhatsApp. We're available to answer questions and arrange consultations at your convenience.

References

Roberts WE, et al. Facial Skin Thickness Changes with Age: High-Resolution Ultrasound Analysis. British Journal of Dermatology. 2024;190(3):412-420.
Chen H, et al. Adenosine Receptor Activation by Salmon Polynucleotides in Dermal Regeneration. Nature Communications. 2024;15:3456.
Kumar A, et al. Fibroblast Response to Salmon DNA Fragments: Quantitative Analysis. Journal of Investigative Dermatology. 2023;143(12):2890-2898.
Wilson DJ, et al. Polynucleotide Therapy for Periorbital Rejuvenation: A Multicentre Study. Ophthalmology and Therapy. 2024;13(2):234-248.
Thompson KL, et al. Optimal Injection Protocols for Facial Polynucleotide Therapy. Plastic and Reconstructive Surgery. 2023;152(4):867-875.
Martinez RS, et al. Combination Therapy with Polynucleotides and PRP: Synergistic Effects. Dermatologic Surgery. 2024;50(1):45-53.
Johnson PE, et al. Injection Techniques for Polynucleotide Administration: Best Practices. Aesthetic Surgery Journal. 2023;43(8):912-920.
Cohen S, et al. Long-term Outcomes of Facial Polynucleotide Therapy. International Journal of Dermatology. 2023;62(9):1123-1131.
Anderson LM, et al. Safety Profile of Salmon DNA Treatments: Large-Scale Analysis. Drug Safety. 2024;47(3):289-297.
Patel NK, et al. Polynucleotides versus Hyaluronic Acid Fillers: Comparative Outcomes. Journal of Cosmetic Dermatology. 2023;22(11):3045-3053.

This article provides educational information about polynucleotide treatments. Individual results vary based on multiple factors. For personalised advice, consult with qualified medical professionals.

Guest User